Brønsted acidic ionic liquid as a metal free catalyst for the one-pot synthesis of α-aminonitriles under mild and solvent-free conditions

Authors

  • Abdol Hajipour Dept. of Pharmacology, University of Wisconsin, Medical School, Madison, 53706-1532, WI, USA. Pharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan 84156, IR Iran.
  • Amin Zarei Department of Science, Fasa Branch, Islamic Azad University, Post Box No 364, Fasa, 7461713591, Fars, Iran.
  • Leila Khazdooz Department of Science, Khorasgan Branch, Islamic Azad University, Isfahan 81595-158, Iran.
  • Nafisehsadat Sheikhan Department of Science, Najafabad Branch, Islamic Azad University, Isfahan, Iran.
Abstract:

An efficient, mild and environmentally friendly method was developed for the Strecker reaction to synthesize α-aminonitriles in the presence of methyl imidazolium hydrogen sulfate ([Hmim][HSO4]) as an efficient catalyst. These syntheses were performed via a one-pot three-component condensation of aldehydes (or ketones), amines, and trimethylsilyl cyanide under mild and solvent free conditions.

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brønsted acidic ionic liquid as a metal free catalyst for the one-pot synthesis of α-aminonitriles under mild and solvent-free conditions

an efficient, mild and environmentally friendly method was developed for the strecker reaction to synthesize α-aminonitriles in the presence of methyl imidazolium hydrogen sulfate ([hmim][hso4]) as an efficient catalyst. these syntheses were performed via a one-pot three-component condensation of aldehydes (or ketones), amines, and trimethylsilyl cyanide under mild and solvent free conditions.

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Journal title

volume 2  issue 2

pages  63- 68

publication date 2012-06-01

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